The murder of Abraham Lincoln set off the greatest manhunt in American history--the pursuit and capture of John Wilkes Booth. From April 14 to April 26, 1865, the assassin led Union cavalry troops on a wild, 12-day chase from the streets of Washington, D.C., across the swamps of Maryland, and into the forests of Virginia, while the nation, still reeling from the just-ended Civil War, watched in horror and sadness.